S03-02. From cell mechanics to tissue morphogenesis
نویسندگان
چکیده
منابع مشابه
S03-02. From cell mechanics to tissue morphogenesis
The planar cell polarity (PCP) signaling pathway is essential for a wide variety of celland tissue-level morphogenetic events in developing embryos. PCP research has been predominantly directed at the role played by a small number of core proteins, including Dishevelled and Frizzled. Much less is known about how these proteins signal downstream to direct the execution of such diverse cell behav...
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Tissue morphogenesis requires the collective, coordinated motion and deformation of a large number of cells. Vertex model simulations for tissue mechanics have been developed to bridge the scales between force generation at the cellular level and tissue deformation and flows. We review here various formulations of vertex models that have been proposed for describing tissues in two and three dim...
متن کاملMechanics of Tissue Morphogenesis
αSMA α-Smooth muscle actin AV Atrioventricular CREB cAMP response element-binding protein dpf Days postfertilization ECM Extracellular matrix EGFR Epidermal growth factor receptor ERK Extracellular signal-regulated kinase FGF10 Fibroblast growth factor 10 HH Hamburger–Hamilton hpf Hours post-fertilization IFP Interstitial fluid pressure IGF Insulin-like growth factor MAPK Mitogen-activated prot...
متن کاملS03-01. Planar cell polarity: Linking developmental regulatory mechanisms to basic cellular machinery during morphogenesis
The planar cell polarity (PCP) signaling pathway is essential for a wide variety of celland tissue-level morphogenetic events in developing embryos. PCP research has been predominantly directed at the role played by a small number of core proteins, including Dishevelled and Frizzled. Much less is known about how these proteins signal downstream to direct the execution of such diverse cell behav...
متن کاملTissue Growth and Morphogenesis: from Genetics to Mechanics and Back (12w5048)
Tissue growth and morphogenesis are fundamental processes in developmental biology. On the cellular level, cell size growth, cell division, and cell shape changes are controlled by signaling molecules that, in turn, are expressed according to a genetic blueprint. On the tissue level, different cell types arrange themselves in spatial patterns that eventually form the tissue or organ. Evidently,...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.949